Capecitabine

Capecitabine

CAT N°: 10487
Price:

From 72.00 61.20

Capecitabine is a prodrug of 5-fluorouracil (5-FU; Item No. 14416).{18418} It is converted to 5-FU via several enzymatic steps beginning in the liver and ending with conversion in tumor tissue by thymidine phosphorylase, an enzyme that is more concentrated in tumor tissue compared with normal tissue. Capecitabine is cytotoxic only at high concentrations in Scaber, SIHA, and MKN45 cells (IC50s = 97, 578, and 994 µM, respectively) and is inactive in a variety of cancer cell lines, including COLO205, HCT116, and MCF-7 cells (IC50s = >1,000 µM).

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5′-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine
  • Correlated keywords
    • Capecitibine Capecytabine Captabin 5-Fluorouracil 5-FU cancers prodrugs thymidine phosphorylase fluoropyrimidine carbamate inhibits inhibition inhibitors thymidylate synthase liver enzymes 158798-73-2 958887-39-3 Deoxyribonucleoside Cytosine Cytosine Deoxyribonucleoside Deoxyriboside Cytosine Cytosine Deoxyriboside Deoxycytidine CDR xeloda
  • Product Overview:
    Capecitabine is a prodrug of 5-fluorouracil (5-FU; Item No. 14416).{18418} It is converted to 5-FU via several enzymatic steps beginning in the liver and ending with conversion in tumor tissue by thymidine phosphorylase, an enzyme that is more concentrated in tumor tissue compared with normal tissue. Capecitabine is cytotoxic only at high concentrations in Scaber, SIHA, and MKN45 cells (IC50s = 97, 578, and 994 µM, respectively) and is inactive in a variety of cancer cell lines, including COLO205, HCT116, and MCF-7 cells (IC50s = >1,000 µM).

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