Calphostin C

Calphostin C

CAT N°: 15383
Price:

From 206.00 175.10

Calphostin C is a metabolite of the fungus C. cladosporioides that specifically inhibits protein kinase C (PKC) (IC50 = 50 nM versus an IC50 > 50 ?M for PKA) by competing at the binding site for diacylglycerol and phorbol esters.{24915} As a polycyclic hydrocarbon with strong absorbance in the visible and ultraviolet ranges, activation of this compound is strictly dependent on exposure to light.{24913} Independent of PKC, calphostin C also directly inhibits phospholipase D1 and D2 (IC50s = 100 nM).{24914} It demonstrates antitumor activity, inhibiting cell growth and promoting apoptosis in HeLa S3 and MCF-7 cells with IC50 values of 0.23 and 0.18 ?M, respectively.{24915}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethyl 4-carbonic acid
  • Correlated keywords
    • UCN-1028C UCNs 1028C UCN1028C inhibitors inhibits inhibitions proteins kinases C PKC D1 PLD1 phospholipases D2 PLD2 antitumors anti tumors anti-tumors apoptosis metabolites fungus C. cladosporioides polycylic hydrocarbons cancers intracellular signaling signals kinases transduction PKFs 115-584 115 584 115584 PKF115-584 PKF-115-584 UCNs 1028C UCN1028C UCN-1028C 125411-36-1 selective activation lights exposures
  • Product Overview:
    Calphostin C is a metabolite of the fungus C. cladosporioides that specifically inhibits protein kinase C (PKC) (IC50 = 50 nM versus an IC50 > 50 ?M for PKA) by competing at the binding site for diacylglycerol and phorbol esters.{24915} As a polycyclic hydrocarbon with strong absorbance in the visible and ultraviolet ranges, activation of this compound is strictly dependent on exposure to light.{24913} Independent of PKC, calphostin C also directly inhibits phospholipase D1 and D2 (IC50s = 100 nM).{24914} It demonstrates antitumor activity, inhibiting cell growth and promoting apoptosis in HeLa S3 and MCF-7 cells with IC50 values of 0.23 and 0.18 ?M, respectively.{24915}

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