Calpain Inhibitor I

Calpain Inhibitor I

CAT N°: 14921
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Calpain inhibitor I is a synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).{23731} At 10-100 ?M calpain inhibitor I dose-dependently prevents the degradation of I?B? and I?B? by the ubiquitin-proteasome complex, which blocks activation of NF?B and the production of TNF and IL-1?, suggesting a potential therapeutic effect for inflammatory diseases.{23732} At 10 ?M, calpain inhibitor I can inhibit nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.{13825}

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