Calpain Inhibitor I

Calpain Inhibitor I

CAT N°: 14921
Price:

From €46.00 €39.10

Calpain inhibitor I is a synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).{23731} At 10-100 ?M calpain inhibitor I dose-dependently prevents the degradation of I?B? and I?B? by the ubiquitin-proteasome complex, which blocks activation of NF?B and the production of TNF and IL-1?, suggesting a potential therapeutic effect for inflammatory diseases.{23732} At 10 ?M, calpain inhibitor I can inhibit nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.{13825}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-L-leucinamide
  • Correlated keywords
    • ALLN N-acetyl-leucyl-leucyl-norleucinal tripeptides aldehydes cysteines proteases inhibits inhibitions calpains I II B cathepsins L ubiquitin-proteasomes ubiquitin complex NF?B nitric oxides NF-kB NF kB genes
  • Product Overview:
    Calpain inhibitor I is a synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).{23731} At 10-100 ?M calpain inhibitor I dose-dependently prevents the degradation of I?B? and I?B? by the ubiquitin-proteasome complex, which blocks activation of NF?B and the production of TNF and IL-1?, suggesting a potential therapeutic effect for inflammatory diseases.{23732} At 10 ?M, calpain inhibitor I can inhibit nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.{13825}

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