€505.00 €429.25
Calcineurin A is the catalytic subunit of calcineurin, a serine/threonine phosphatase with roles in T cell activation, cardiac function, learning and memory, apoptosis, and cell cycle regulation.{61745,61746} Calcineurin A has three isoforms, ?, ?, and ?, which are encoded by PPP3CA, PPP3CB, and PPP3CC, respectively. Calcineurin A ? is composed of an N-terminal catalytical domain, binding regions for the regulatory subunit calcineurin B (Item No. 34631) and the binding partner calmodulin, and a C-terminal autoinhibitory domain.{60846,60847} It is ubiquitously expressed and associates with calcineurin B and calmodulin in a calcium-dependent manner.{60848,60849} Calcineurin A ? has roles in kidney development and function, as well as Tau dephosphorylation, but is dispensable for T cell development.{60849} Calcineurin A ?-null mice exhibit impaired kidney function, failure to thrive, and shortened lifespan. Brain calcineurin A ? levels are inversely correlated with disease severity in patients with Alzheimer’s disease.{60850} Cayman’s Calcineurin A ? Isoform (human, recombinant) protein can be used for binding assays. This protein consists of 538 amino acids and has a calculated molecular weight of 60.8 kDa.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 50 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | Lyophilized from sterile 20 mM Tris, pH 8.0, with 500 mM sodium chloride and 10% glycerol |
| Purity | ≥94% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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