C527

C527

CAT N°: 21771
Price:

From 122.00 103.70

C527 is an inhibitor of USP1/UAF complex deubiquitinase activity (IC50 = 0.88 µM).{36957} It also inhibits USP5, UCL-H3, and USP12/46 but not UCL-H1 activity (IC50s = 1.65, 2.18, 5.97, and >10 µM, respectively). C527 increases ubiquinated Fanconi anemia complementation group D2 (FANCD2-Ub) and FANCI-Ub levels in a concentration-dependent manner. It inhibits homologous recombination repair, cell proliferation, and sensitizes HeLa cells to the DNA crosslinker mitomycin C (Item No. 11435). C527 also inhibits proliferation of PC3 and LNCap prostate cancer cells (IC50s = 0.24 and 0.03 µM, respectively, after 72 hours).{36958}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-(4-fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione
  • Correlated keywords
    • C-527 USP-5 UCLH3 1 USP-12/46 PC-3 D-2
  • Product Overview:
    C527 is an inhibitor of USP1/UAF complex deubiquitinase activity (IC50 = 0.88 µM).{36957} It also inhibits USP5, UCL-H3, and USP12/46 but not UCL-H1 activity (IC50s = 1.65, 2.18, 5.97, and >10 µM, respectively). C527 increases ubiquinated Fanconi anemia complementation group D2 (FANCD2-Ub) and FANCI-Ub levels in a concentration-dependent manner. It inhibits homologous recombination repair, cell proliferation, and sensitizes HeLa cells to the DNA crosslinker mitomycin C (Item No. 11435). C527 also inhibits proliferation of PC3 and LNCap prostate cancer cells (IC50s = 0.24 and 0.03 µM, respectively, after 72 hours).{36958}

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