C4 Ceramide (d18:1/4:0)

C4 Ceramide (d18:1/4:0)

CAT N°: 22528
Price:

From 94.00 79.90

C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.{13011,48234,48235} It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) when used at a concentration of 10 ?M.{13011} C4 Ceramide is cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 ?M, respectively).{48234} C4 Ceramide also increases maturation and stability of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation, enhances cAMP-activated chloride secretion, and suppresses secretion of IL-8 in primary epithelial cells isolated from patients with cystic fibrosis.{48235}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-butanamide
  • Correlated keywords
    • 111122-58-8 C 4 IL4 interleukin EL SKBR3 SKBR BR3 MCF7 CF TR F 508 del IL8 erythrosphingosine
  • Product Overview:
    C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.{13011,48234,48235} It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) when used at a concentration of 10 ?M.{13011} C4 Ceramide is cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 ?M, respectively).{48234} C4 Ceramide also increases maturation and stability of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation, enhances cAMP-activated chloride secretion, and suppresses secretion of IL-8 in primary epithelial cells isolated from patients with cystic fibrosis.{48235}

We also advise you