C-Type Natriuretic Peptide-22 (human, porcine, rat) (trifluoro<wbr/>acetate salt)

C-Type Natriuretic Peptide-22 (human, porcine, rat) (trifluoroacetate salt)

CAT N°: 24401
Price:

From €310.00 €263.50

C-Type natriuretic peptide-22 (CNP-22) is an endogenous peptide with diverse biological activities.{39460,39461,39462} Its 22 amino acid sequence corresponds to residues 105-126 of its precursors prepro CNP, pro CNP, and CNP-53.{39461} CNP-22 is a selective agonist of natriuretic peptide receptors (NPRs) 2 and 3 (Kds = 7, 10.8, and >500,000 pM for NPR2, 3, and 1, respectively).{39460} It stimulates cGMP accumulation in HEK293 cells expressing rat NPR2 (ED50 = 2.2 nM) and relaxes isolated rat cerebral arterioles (EC50 = 0.52 nM).{39463,39464} In vivo, CNP-22 (25 ?g/kg) decreases kidney injury and oxidative and inflammatory responses in a rat model of hemorrhagic shock.{39465}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • glycyl-L-leucyl-L-seryl-L-lysylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-leucyl-L-lysyl-L-leucyl-L-?-aspartyl-L-arginyl-L-isoleucylglycyl-L-seryl-L-methionyl-L-serylglycyl-L-leucylglycyl-L-cysteine cyclic (6?22)-disulfide, trifluoroacetate salt
  • Correlated keywords
    • 127869-51-6 CNP22 NPR-2 CNP53 HEK-293 proCNP 1-22 factor
  • Product Overview:
    C-Type natriuretic peptide-22 (CNP-22) is an endogenous peptide with diverse biological activities.{39460,39461,39462} Its 22 amino acid sequence corresponds to residues 105-126 of its precursors prepro CNP, pro CNP, and CNP-53.{39461} CNP-22 is a selective agonist of natriuretic peptide receptors (NPRs) 2 and 3 (Kds = 7, 10.8, and >500,000 pM for NPR2, 3, and 1, respectively).{39460} It stimulates cGMP accumulation in HEK293 cells expressing rat NPR2 (ED50 = 2.2 nM) and relaxes isolated rat cerebral arterioles (EC50 = 0.52 nM).{39463,39464} In vivo, CNP-22 (25 ?g/kg) decreases kidney injury and oxidative and inflammatory responses in a rat model of hemorrhagic shock.{39465}

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