BTB-1

BTB-1

CAT N°: 27219
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BTB-1 is a reversible inhibitor of the kinesin-8 family motor protein Kif18A (IC50 = 1.69 ?M).{46312} It is selective for Kif18A over a panel of seven kinesins at 100 ?M. BTB-1 (100 ?M) inhibits Kif18A-dependent microtubule motility in a microtubule gliding assay. It induces mitotic accumulation of HeLa cells in a dose-dependent manner.

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