Brevetoxin B

Brevetoxin B

CAT N°: 10011498
Price:

414.00 351.90

Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.{31511,31512} Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.{31512}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • brevetoxin B
  • Correlated keywords
    • ichthyotoxic neurotoxin neurotoxic polyketide BTXB PbTx2 GbTx2 T 34 T34 GB 2 GB2 Gymnodinium ptychodiscus brevis T 4-7 T47 T4-7 Na
  • Product Overview:
    Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.{31511,31512} Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.{31512}

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