BRD7 bromodomain (human, recombinant)

Territorial Availability: Available through Bertin Technologies only in France

• Correlated keywords
  • genes regulations epigenetics chromatin reseach cancers recombinants proteins histones acetylation bromodomain lysine residues domains transcriptions nucleosomes regulating regulates targets promoters subunits polybromo-associated BRG1 PBAF components SW1/SNF remodeling complexes tumors supressors cofactors p53 breasts tumorigenicity BRCA1 dependents estrogen receptors ? expressions nasopharyngeal carcinomas colorectal transcriptional silencing PRMT5 PRC2 regions complex 2 switch sucrose breasts cancers type 1 proteins arginine methyltransferases 5 polycomb repressive non-fermentable
• Product Overview:
  The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain.{19952} These domains function in linking protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters.{20313} BRD7 is a subunit of the polybromo-associated BRG1-associated factor (PBAF)-specific component of the switch/sucrose non-fermentable chromatin-remodeling complex.{23106} It has a tumor suppressor role by acting as a cofactor for p53 and regulating breast cancer tumorigenicity.{23107,23108} Cells lacking BRD7 have reduced breast cancer type 1-dependent estrogen receptor ? expression.{23108} Down-regulation of BRD7 has been demonstrated in nasopharyngeal carcinoma cell lines and in colorectal cancer.{23109,23107} BRD7 is also involved in transcriptional gene silencing through binding to protein arginine methyltransferase 5 and polycomb repressive complex 2. This protein product contains the bromodomain region of BRD7.