Amyloid-? (1-8, A2V) Peptide
Amyloid-? (1-8, A2V) Peptide
Amyloid-? (1-8, A2V) is a truncated form of amyloid-? (A?) that contains a valine to alanine substitution at position 2...
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From €43.00 €36.55
Bradykinin is an endogenous vasodilator that is also involved in inflammation.{5716,67125} It is formed from kininogen via cleavage of high molecular weight kininogen (HMWK) by kallikrein or prekallikrein in a Factor XIIa-dependent or -independent manner.{67126} Bradykinin binds to the bradykinin B2 receptor (IC50 = 0.54 nM in COS-7 cells expressing the human receptor) and acts as an agonist but does not bind the bradykinin B1 receptor (Ki = >10,000 nM in HEK293 cells expressing the human receptor).{49601,49599} It stimulates arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) release in CHO cells expressing the human bradykinin B2 receptor (EC50 = 0.7 nM).{49601} Bradykinin (100 nM) induces relaxation of isolated porcine coronary arterial rings precontracted with acetylcholine (ACh; Item No. 23829) or phorbol 12,13-dibutyrate (PDBu; Item No. 27785).{5716} It induces hyperalgesia in mice when administered at a dose of 1 µg/paw, an effect that can be reversed by the bradykinin B2 antagonist icatibant (HOE 140; Item No. 24083).{67125} Plasma levels of bradykinin are increased in patients during an acute attack of angioedema.{67127}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 03/03/6846 00:00 |
| Molecular formula | C50H73N15O11 • XC2H4O2 |
| Smiles | CC(O)=O.O=C(N(CCC1)[C@@H]1C(NCC(N[C@H](C(N[C@@H](CO)C(N(CCC2)[C@@H]2C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CC=CC=C4)=O)=O)[C@H](CCC5)N5C([C@@H](N)CCCNC(N)=N)=O |
| Molecular weight | 1060,2 |
| Custom code | 2933.99 |
| Formulation | A solid |
| Purity | >98% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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