Bobcat 339

Bobcat 339

CAT N°: 31453
Price:

From 92.00 78.20

Bobcat 339 is a cytosine derivative that was originally found to be an inhibitor of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) and TET2 (IC50s = 33 and 73 µM, respectively, in cell-free assays).{61034} However, it was found that the TET inhibitory activity was due to residual copper in the Bobcat 339 preparation used for the experiments.{65280} Copper-containing Bobcat 339 (10 µM) also reduces DNA 5-hydroxymethylcytosine (5-hmC) levels in HT22 hippocampal neurons, but copper-free preparations of Bobcat 339 (50 µM) do not reduce DNA 5-hmC levels in Hep3B cells.{61034,65280}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-amino-1-[1,1?-biphenyl]-3-yl-5-chloro-2(1H)-pyrimidinone
  • Correlated keywords
    • Bobcat339 TET-1 2 5hmC HT-22 Hep-3B BC-339
  • Product Overview:
    Bobcat 339 is a cytosine derivative that was originally found to be an inhibitor of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) and TET2 (IC50s = 33 and 73 µM, respectively, in cell-free assays).{61034} However, it was found that the TET inhibitory activity was due to residual copper in the Bobcat 339 preparation used for the experiments.{65280} Copper-containing Bobcat 339 (10 µM) also reduces DNA 5-hydroxymethylcytosine (5-hmC) levels in HT22 hippocampal neurons, but copper-free preparations of Bobcat 339 (50 µM) do not reduce DNA 5-hmC levels in Hep3B cells.{61034,65280}

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