BO-264

BO-264

CAT N°: 36611
Price:

From 100.00 85.00

BO-264 is a transforming acidic coiled-coil containing protein 3 (TACC3) inhibitor.{66140} It binds to TACC3 in thermal shift and drug affinity responsive target stability (DARTS) assays and inhibits the growth of JIMT-1, HCC1954, MDA-MB-231, MDA-MB-436, and CAL-51 cancer cells (IC50s = 0.19, 0.16, 0.12, 0.13, and 0.36 µM, respectively). BO-264 is cytotoxic to RT4 cells that endogenously express TACC3-FGFR3 fusion proteins (IC50 = 3.66 µM). It induces mitotic arrest, apoptosis, and aberrant spindle formation and reduces centrosomal localization of TACC3 in JIMT-1 cells. BO-264 (25 mg/kg) reduces tumor volume and increases median survival in an EMT6 mouse xenograft model.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)-4-pyrimidinamine
  • Correlated keywords
    • BO264 TACC JIMT1 HCC-1954 MDAMB231 MDAMB MB231 MB436 MDAMB436 CAL51 RT-4 TACC3FGFR3 FGFR-3 JIMT1 EMT-6
  • Product Overview:
    BO-264 is a transforming acidic coiled-coil containing protein 3 (TACC3) inhibitor.{66140} It binds to TACC3 in thermal shift and drug affinity responsive target stability (DARTS) assays and inhibits the growth of JIMT-1, HCC1954, MDA-MB-231, MDA-MB-436, and CAL-51 cancer cells (IC50s = 0.19, 0.16, 0.12, 0.13, and 0.36 µM, respectively). BO-264 is cytotoxic to RT4 cells that endogenously express TACC3-FGFR3 fusion proteins (IC50 = 3.66 µM). It induces mitotic arrest, apoptosis, and aberrant spindle formation and reduces centrosomal localization of TACC3 in JIMT-1 cells. BO-264 (25 mg/kg) reduces tumor volume and increases median survival in an EMT6 mouse xenograft model.

We also advise you