BMS 833923

BMS 833923

CAT N°: 16240
Price:

From 92.00 78.20

Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors.{21774} BMS 833923 is an orally bioavailable inhibitor of Smo.{27708,27709} It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-benzamide
  • Correlated keywords
    • biochemical inhibitor receptor antagonist stem cell research signal transduction cancer inhibit oral bioavailable SMO smoothened surface Patched mediate sonic hedgehog Shh block binding BODIPY cyclopamine Gli activation line expression wild-type activate mutant form prevention tumor growth medullablastoma pancreatic pancreas carcinoma xenograft model XL139 BMS833923
  • Product Overview:
    Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors.{21774} BMS 833923 is an orally bioavailable inhibitor of Smo.{27708,27709} It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models.

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