BMS 345541 (hydrochloride)

BMS 345541 (hydrochloride)

CAT N°: 16667
Price:

66.00 56.10

BMS 345541 is a cell permeable inhibitor of the I?B kinases IKK? and IKK? (IC50s = 4 and 0.3 µM).{27271} It is without effect against a panel of other serine/threonine and tyrosine kinases at 100 µM.{27271} BMS 345541 inhibits signaling through nuclear factor-?B (NF-?B) both in cells and in vivo, showing excellent pharmacokinetics in mice.{27271} It blocks joint inflammation and damage in collagen-induced arthritis in mice and induces apoptosis in melanoma cells both in vitro and in vivo.{27267,27270} BMS 345541 is used to explore novel roles for IKK phosphorylation and NF-?B signaling.{27268,27269}

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