BMS-265246

BMS-265246

CAT N°: 19168
Price:

From 92.00 78.20

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.{21810} BMS-265246 is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin E (IC50s = 6 and 9 nM, respectively).{30908} It less potently inhibits Cdk4/cyclin D (IC50 = 0.23 ?M).{30908} BMS-265246 blocks the cycling of HCT116 cells (EC50 = 0.29-0.49 µM), resulting in cell cycle arrest in G2 phase.{30909}

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