BMS 191011

BMS 191011

CAT N°: 22299
Price:

From 136.00 115.60

BMS 191011 is an activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels that increases maximum potassium current to 126% of control in X. laevis oocytes expressing human KCa1.1 channels when used at a concentration of 1 ?M.{47157} In vivo, BMS 191011 (10-100 ?g/kg, i.v.) increases the diameter of retinal arterioles without affecting blood pressure or heart rate in rats, an effect that is reversed by the KCa1.1 channel blocker iberiotoxin (Item No. 14608).{47158}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one
  • Correlated keywords
    • 213190-46-6 BMS191011 Xenopus BK CA BMS-A BMSA
  • Product Overview:
    BMS 191011 is an activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels that increases maximum potassium current to 126% of control in X. laevis oocytes expressing human KCa1.1 channels when used at a concentration of 1 ?M.{47157} In vivo, BMS 191011 (10-100 ?g/kg, i.v.) increases the diameter of retinal arterioles without affecting blood pressure or heart rate in rats, an effect that is reversed by the KCa1.1 channel blocker iberiotoxin (Item No. 14608).{47158}

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