BMP-22

BMP-22

CAT N°: 27264
Price:

165.00 140.25

BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM).{35710} It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 ?M. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC; Item No. 24331) in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis.

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