BML-278

BML-278

CAT N°: 20209
Price:

From 48.00 40.80

BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 µM.{34113} It less potently activates SIRT2 and SIRT3 (EC150s = 25 and 50 µM, respectively).{34113} BML-278 induces hypoacetylation on ?-tubulin in U937 cells that are pretreated with SAHA (Item No. 10009929), a histone deacetylase inhibitor. It arrests cell cycling at the G1/S phase, reduces senescence in primary human mesenchymal cells, and significantly increases mitochondrial density in murine C2C12 myoblasts.{34113}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1,4-dihydro-4-phenyl-1-(phenylmethyl)-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester
  • Correlated keywords
    • BML278 SIRT-1 2 3 a-tubulin U-937 G-1 HDAC dihydropyridine dicarboxylate
  • Product Overview:
    BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 µM.{34113} It less potently activates SIRT2 and SIRT3 (EC150s = 25 and 50 µM, respectively).{34113} BML-278 induces hypoacetylation on ?-tubulin in U937 cells that are pretreated with SAHA (Item No. 10009929), a histone deacetylase inhibitor. It arrests cell cycling at the G1/S phase, reduces senescence in primary human mesenchymal cells, and significantly increases mitochondrial density in murine C2C12 myoblasts.{34113}

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