BIX02188

BIX02188

CAT N°: 16238
Price:

From 66.00 56.10

BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGF?R1 (IC50s = 810 and 1,800 nM, respectively).{27914} It does not inhibit the closely related kinases MEK1, MEK2, ERK2, and JNK2 (IC50s = > 6,300 nM).{27914} BIX02188 inhibits phosphorylation of ERK5 in a dose-dependent manner without affecting phosphorylation of ERK1/2, p38 MAPK, or JNK1/2.{27914}

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