Bisindolyl<wbr/>maleimide X (hydro<wbr>chloride)

Bisindolylmaleimide X (hydrochloride)

CAT N°: 17511
Price:

From 96.00 81.60

Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).{17342} It has been shown to inhibit PKC?, ?I, ?II, ?, and ? with IC50 values of 8, 8, 14, 13, and 39 nM, respectively.{17342} It has also been identified as an inhibitor of Cdk2 (IC50 = 200 nM) and GSK3?/?.{28472} This compound has been used to activate mesenchymal stem cells, increase the surface expression of homing ligands that bind to intercellular adhesion molecule 1, and target delivery of these cells to sites of inflammation.{28473}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione, monohydrochloride
  • Correlated keywords
    • 131848-97-0 protein kinase PKC inhibitor Cdk2 GSK-3 ?/? intracellular signaling stem cell research inflammation biochemical inhibit signal transduction 131848-97-0 permeable inhibit BIMX Ro318425 318425 reversible ATP-competitive PKC? ?I ?II ? ? GSK3 ?? GSK3?? activate mesenchymal homing ligand adhesion molecule 1 318425
  • Product Overview:
    Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).{17342} It has been shown to inhibit PKC?, ?I, ?II, ?, and ? with IC50 values of 8, 8, 14, 13, and 39 nM, respectively.{17342} It has also been identified as an inhibitor of Cdk2 (IC50 = 200 nM) and GSK3?/?.{28472} This compound has been used to activate mesenchymal stem cells, increase the surface expression of homing ligands that bind to intercellular adhesion molecule 1, and target delivery of these cells to sites of inflammation.{28473}

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