Biotin-VAD-FMK

Biotin-VAD-FMK

CAT N°: 24305
Price:

653.00 555.05

Biotin-VAD-FMK is a biotin-conjugated form of the cell-permeable caspase inhibitor Z-VAD(OMe)-FMK (Item No. 14463).{9853} It is an affinity probe that allows for detection and immobilization of caspases using the biotin ligand. Biotin-VAD-FMK inhibits caspase-3-like activity in a dose-dependent manner in hepatocytes stimulated with TNF-? and ActD. It also binds to caspase-3 and caspase-8 in hepatocyte lysates, an effect that can be blocked by the caspase inhibitor Ac-DEVD-CHO (Item No. 10017).

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • methyl (3S,6S,9S)-3-(2-fluoroacetyl)-9-isopropyl-6-methyl-5,8,11,18-tetraoxo-22-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10,17-tetraazadocosanoate
  • Correlated keywords
    • Biotin-Val-Ala-Asp(OMe)-Fluoromethyl ketone VADFMK TNF? Act-D
  • Product Overview:
    Biotin-VAD-FMK is a biotin-conjugated form of the cell-permeable caspase inhibitor Z-VAD(OMe)-FMK (Item No. 14463).{9853} It is an affinity probe that allows for detection and immobilization of caspases using the biotin ligand. Biotin-VAD-FMK inhibits caspase-3-like activity in a dose-dependent manner in hepatocytes stimulated with TNF-? and ActD. It also binds to caspase-3 and caspase-8 in hepatocyte lysates, an effect that can be blocked by the caspase inhibitor Ac-DEVD-CHO (Item No. 10017).

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