Nrf2 (C-Term) Polyclonal Antibody
Nrf2 (C-Term) Polyclonal Antibody
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor encoded by NFE2L2 in humans that...
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€598.00 €508.30
€598.00 €508.30
Big endothelin-1 (BET-1) (1-38) is a peptide precursor of endothelin-1 (Item No. 24127) produced by vascular smooth muscle and endothelium.{42221} BET-1 is converted to endothelin-1 by endothelin-converting enzyme (ECE) and to endothelin-1 (1-31) by chymase.{42222} It is also converted to endothelin-1 (1-32) by matrix metalloproteinase-2 (MMP-2).{42221} BET-1 (50 pmol) induces vasoconstriction in isolated rat mesenteric arteries, an effect that is blocked by the MMP-2 antagonist TIMP-2. In vivo, BET-1 (0.1-10 nmol/kg, i.v.) dose-dependently increases blood pressure and bradycardia and leads to renal and hindquarter vasoconstriction in rats as well as abdominal constriction in mice (ED50 = 0.043 mg/kg), effects that are reversed or prevented by the ECE inhibitor phosphoramidon (Item No. 15113).{42223,42224} It also induces mesenteric vasoconstriction in rats.{42223} Unlike endothelin-1, BET-1 (100 pmol/kg, i.v.) increases water and sodium excretion in rats independent of the endothelin A receptor.{42225}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 500 µg |
|---|---|
| Shipping | dry ice |
| Molecular formula | C189H282N48O56S5• XCF3COOH |
| Smiles | [H]N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C1=O)=O)=O)CC(O)=O)=O)CCSC)=O)=O)=O)=O)CSSC[C@H](N1)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C2=O)CC3=CC=CC=C3)=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)CSSC[C@H](N2)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N5CCC[C@H]5C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N6CCC[C@H]6C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(NCC(N[C@@H](CO)C(N7CCC[C@H]7C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)CC8=CC=C(O)C=C8)=O)=O)=O)=O)CC9=CN=CN9)=O)=O)=O)=O)=O)=O)CC=CNC=CC=CC=C)=O)=O)=O)CC(O)=O)=O)=O)CC=CN=CN)=O.FC(F)(C(O)=O)F |
| Molecular weight | 4282,9 |
| Formulation | A lyophilized powder |
| Purity | ≥95% |
| Custom code | 3504.00 |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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