Big Endothelin-1 (1-38) (human) (trifluoro<wbr/>acetate salt)

Big Endothelin-1 (1-38) (human) (trifluoroacetate salt)

CAT N°: 24959
Price:

€598.00 €508.30

Big endothelin-1 (BET-1) (1-38) is a peptide precursor of endothelin-1 (Item No. 24127) produced by vascular smooth muscle and endothelium.{42221} BET-1 is converted to endothelin-1 by endothelin-converting enzyme (ECE) and to endothelin-1 (1-31) by chymase.{42222} It is also converted to endothelin-1 (1-32) by matrix metalloproteinase-2 (MMP-2).{42221} BET-1 (50 pmol) induces vasoconstriction in isolated rat mesenteric arteries, an effect that is blocked by the MMP-2 antagonist TIMP-2. In vivo, BET-1 (0.1-10 nmol/kg, i.v.) dose-dependently increases blood pressure and bradycardia and leads to renal and hindquarter vasoconstriction in rats as well as abdominal constriction in mice (ED50 = 0.043 mg/kg), effects that are reversed or prevented by the ECE inhibitor phosphoramidon (Item No. 15113).{42223,42224} It also induces mesenteric vasoconstriction in rats.{42223} Unlike endothelin-1, BET-1 (100 pmol/kg, i.v.) increases water and sodium excretion in rats independent of the endothelin A receptor.{42225}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • L-cysteinyl-L-seryl-L-cysteinyl-L-seryl-L-seryl-L-leucyl-L-methionyl-L-?-aspartyl-L-lysyl-L-?-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-cysteinyl-L-histidyl-L-leucyl-L-?-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-valyl-L-asparaginyl-L-threonyl-L-prolyl-L-?-glutamyl-L-histidyl-L-valyl-L-valyl-L-prolyl-L-tyrosylglycyl-L-leucylglycyl-L-seryl-L-prolyl-L-arginyl-L-serine, cyclic (1?15),(3?11)-bis(disulfide), trifluoroacetate salt
  • Correlated keywords
    • 121014-53-7 131714-51-7 153129-90-9 120796-97-6 BET1 hET-38 proendothelin het38 MMP2 TIMP2
  • Product Overview:
    Big endothelin-1 (BET-1) (1-38) is a peptide precursor of endothelin-1 (Item No. 24127) produced by vascular smooth muscle and endothelium.{42221} BET-1 is converted to endothelin-1 by endothelin-converting enzyme (ECE) and to endothelin-1 (1-31) by chymase.{42222} It is also converted to endothelin-1 (1-32) by matrix metalloproteinase-2 (MMP-2).{42221} BET-1 (50 pmol) induces vasoconstriction in isolated rat mesenteric arteries, an effect that is blocked by the MMP-2 antagonist TIMP-2. In vivo, BET-1 (0.1-10 nmol/kg, i.v.) dose-dependently increases blood pressure and bradycardia and leads to renal and hindquarter vasoconstriction in rats as well as abdominal constriction in mice (ED50 = 0.043 mg/kg), effects that are reversed or prevented by the ECE inhibitor phosphoramidon (Item No. 15113).{42223,42224} It also induces mesenteric vasoconstriction in rats.{42223} Unlike endothelin-1, BET-1 (100 pmol/kg, i.v.) increases water and sodium excretion in rats independent of the endothelin A receptor.{42225}

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