BI-<wbr/>D1870

BI-D1870

CAT N°: 15264
Price:

From 83.00 70.55

The 90 kDa ribosomal S6 kinases (RSKs) are a group of serine/threonine kinases involved in diverse cellular processes, including growth, survival, and motility.{24631} BI-D1870 is a cell permeable, ATP-competitive inhibitor of the four vertebrate isoforms of RSK, RSK1-4 (IC50s = 31, 24, 18, and 15 nM, respectively).{24632} At 100 nM, it also significantly inhibits polo-like kinase 1, Aurora B, maternal embryonic leucine zipper kinase, and mammalian STE20-like kinase 2.{24632,17331} BI-D1870 acts at the N-terminal kinase domain, but not the C-terminal domain, of RSK.{24632,17331}

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