BG45

BG45

CAT N°: 16918
Price:

From 122.00 103.70

BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 µM, respectively).{27757} At concentrations up to 50 mg/kg, BG45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.{27757}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-(2-aminophenyl)-2-pyrazinecarboxamide
  • Correlated keywords
    • HDAC3 inhibitor histone deacetylase tumor multiple myeloma biochemical cancer chromatin research epigenetics modification inhibit HDAC-3 BG-45 class I selectivity HDAC1 HDAC2 HDAC6 HDAC-1 HDAC-2 HDAC-6 bortezomib dose-dependently growth mouse model
  • Product Overview:
    BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 µM, respectively).{27757} At concentrations up to 50 mg/kg, BG45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.{27757}

We also advise you