Betamethasone

Betamethasone

CAT N°: 20363
Price:

From 80.00 68.00

Betamethasone is a synthetic corticosteroid.{64715} In vivo, betamethasone (5 mg/kg) reduces bronchoalveolar lavage fluid (BALF) matrix metalloproteinase-2 (MMP-2) and MMP-9 activities, TNF-? levels, and neutrophil number in a mouse model of LPS-induced lung injury. Prenatal administration of betamethasone (0.1 mg/kg) improves neonatal lung function but decreases hippocampal and corpus callosum neuron density and induces motor function deficits in a rabbit model of late preterm birth.{64716} It also extends gestational length in a rat model of preterm labor induced by high mobility group protein B1 (HMGB1).{64717} Formulations containing betamethasone have been used in the treatment of inflammatory skin conditions and prenatally to promote fetal lung maturation.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 9-fluoro-11?,17,21-trihydroxy-16?-methyl-pregna-1,4-diene-3,20-dione
  • Correlated keywords
    • MMP2 MMP9 HMG NSC39470 SCH4831
  • Product Overview:
    Betamethasone is a synthetic corticosteroid.{64715} In vivo, betamethasone (5 mg/kg) reduces bronchoalveolar lavage fluid (BALF) matrix metalloproteinase-2 (MMP-2) and MMP-9 activities, TNF-? levels, and neutrophil number in a mouse model of LPS-induced lung injury. Prenatal administration of betamethasone (0.1 mg/kg) improves neonatal lung function but decreases hippocampal and corpus callosum neuron density and induces motor function deficits in a rabbit model of late preterm birth.{64716} It also extends gestational length in a rat model of preterm labor induced by high mobility group protein B1 (HMGB1).{64717} Formulations containing betamethasone have been used in the treatment of inflammatory skin conditions and prenatally to promote fetal lung maturation.

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