CAY10410

CAY10410

CAT N°: 18590
Price:

131.00 111.35

CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPAR? ligand activity and resistance to metabolism. 15-deoxy-?12,14-PGJ2 has been shown to be a potent ligand for PPAR?.{1424} Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and ?12-PGJ2 occurs via glutathione addition across the ?,? unsaturated enone.{7193} CAY10410 was designed as an analog of the PPAR?-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 µM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 µM.{12676}

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