Benznidazole

Benznidazole

CAT N°: 29090
Price:

From 159.00 135.15

Benznidazole is an orally bioavailable antiprotozoal agent.{48626} It is a 2-nitroimidazole prodrug that becomes active when the nitro group is reduced within the parasite.{48630} It inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 ?M, respectively).{48627,48628} It also inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions when used at a concentration of 100 ?M.{48629} Benznidazole (100 mg/kg per day) decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease.{48626} Formulations containing benznidazole have been used in the treatment of Chagas disease caused by T. cruzi.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide
  • Correlated keywords
    • anti protozoal Trypanosoma Trichomoniasis Giardia Entamoeba C 33A C33 A KNS 42 Benznidazol Benzonidazol Benzonidazole NSC299972 Ro071051 Ro07 071051 Radanil
  • Product Overview:
    Benznidazole is an orally bioavailable antiprotozoal agent.{48626} It is a 2-nitroimidazole prodrug that becomes active when the nitro group is reduced within the parasite.{48630} It inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 ?M, respectively).{48627,48628} It also inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions when used at a concentration of 100 ?M.{48629} Benznidazole (100 mg/kg per day) decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease.{48626} Formulations containing benznidazole have been used in the treatment of Chagas disease caused by T. cruzi.

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