€724.00 €615.40
Beclin 1 (BECN1) is a core component of the class III phosphatidylinositol 3-kinase (PI3K) complex, which generates phosphatidylinositol 3-phosphate (PI3P) and has functions in macroautophagy and the endocytic pathway when associated with ATG14 and UVRAG, respectively.{43560} BECN1 is comprised of a BH3 domain involved in Bcl-2/Bcl-xL binding, a coiled-coil domain, and an evolutionarily conserved domain (ECD) that is required for association with the PI3K complex.{43562,43563} Binding of BECN1 to various BECN1-interacting proteins can regulate the activity of the ATG14-containing PI3K complex, which is required for nucleation of the phagophore during macroautophagy.{43560,43561} Binding of the anti-apoptotic protein Bcl-2 to BECN1 prevents the association of BECN1 with the PI3K complex and inhibits autophagy, whereas AMBRA1, which also binds directly to BECN1, positively regulates the PI3K complex to facilitate autophagy.{43560,43563} Transfection of autophagy-deficient MCF-7 human breast cancer cells with wild-type BECN1, but not a BECN1 mutant lacking the ECD, increases starvation-induced autophagy in vitro and inhibits tumor growth in an MCF-7 mouse xenograft model, indicating that BECN1 has ECD-dependent tumor suppressor activity.{43562} BECN1 heterozygous mice expressing human amyloid precursor protein (APP+Becn1+/- mice) have decreased autophagy in the cerebral cortex, increased extracellular amyloid-? (A?) deposits in the frontal cortex, and increased intraneuronal A? accumulation in the hippocampus and frontoparietal cortex compared to APP+Becn1+/+ mice.{43564} BECN1 may also have roles in ischemia/reperfusion injury, Niemann-Pick type C disease, and protection against viral infection.{43563}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Purity | ≥80% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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