Batimastat

Batimastat

CAT N°: 14742
Price:

From 92.00 78.20

Batimastat is a broad spectrum inhibitor of matrix metalloproteinases (MMP), with IC50 values of 1-5 nM for all MMPs tested, including MMP-1, -2, -3, -7, -9, -13, and -14.{25118,25119,25120,25121} It also potently inhibits TNF?-converting enzyme (IC50 = 14.9 nM).{25119} Because of its action on MMPs, batimastat has anti-proliferative, anti-invasive, and anti-metastatic actions that are relevant, in particular, to cancer.{25117} Batimastat less effectively inhibits the processing of the low affinity IgE receptor CD23 (IC50 = 100 nM).{25122}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (2R,3S)-N4-hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]-butanediamide
  • Correlated keywords
    • inhibitors cancers inhibits inhibitions proteases potent broad MMPs matrix metalloproteinases anti-proliferative anti proliferative antiproliferative anti-invasive antiinvasive invasive anti-metastatic metastatic antimetastatic BBs BB94 94 BB-9 MMP-1 MMP-2 MMP-3 MMP-7 MMP-9 MMP-13 MMP-14 1 2 3 7 9 13 14 TNF?-converting enzymes TNF.alpha.-converting TNFa-converting TNFalpha-converting TNF ? .alpha. a alpha converting anti-proliferative TACE
  • Product Overview:
    Batimastat is a broad spectrum inhibitor of matrix metalloproteinases (MMP), with IC50 values of 1-5 nM for all MMPs tested, including MMP-1, -2, -3, -7, -9, -13, and -14.{25118,25119,25120,25121} It also potently inhibits TNF?-converting enzyme (IC50 = 14.9 nM).{25119} Because of its action on MMPs, batimastat has anti-proliferative, anti-invasive, and anti-metastatic actions that are relevant, in particular, to cancer.{25117} Batimastat less effectively inhibits the processing of the low affinity IgE receptor CD23 (IC50 = 100 nM).{25122}

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