BAN ORL 24 (hydrochloride)

BAN ORL 24 (hydrochloride)

CAT N°: 29485
Price:

From 109.00 92.65

BAN ORL 24 is an antagonist of the nociceptin (NOP) receptor (Ki = 0.24 nM in a radioligand binding assay using CHO cell membranes expressing the human receptor).{62409} It is selective for NOP receptors over ?-, ?-, and ?-opioid receptors (Kis = 0.19, 0.34, and >1 µM, respectively). BAN ORL 24 reduces NOP-induced GTP?S binding (pA2 = 9.98) and calcium mobilization (KB = 0.93 nM) in CHO cells. It inhibits electrically induced twitches in isolated mouse and rat vas deferens, as well as isolated guinea pig ileum, when used at a concentration of 100 nM. BAN ORL 24 (10 mg/kg) reverses thermal and mechanical antinociceptive activities induced by the dual agonist of µ-opioid and NOP receptors BPR1M97 in mice.{62410}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-(phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4?-piperidin]-1?-yl)propyl]-2-pyrrolidinecarboxamide, dihydrochloride
  • Correlated keywords
    • 475150-69-7 BANORL24 BANORL BPR1M-97 BPR-1M97 BPR1-M97
  • Product Overview:
    BAN ORL 24 is an antagonist of the nociceptin (NOP) receptor (Ki = 0.24 nM in a radioligand binding assay using CHO cell membranes expressing the human receptor).{62409} It is selective for NOP receptors over ?-, ?-, and ?-opioid receptors (Kis = 0.19, 0.34, and >1 µM, respectively). BAN ORL 24 reduces NOP-induced GTP?S binding (pA2 = 9.98) and calcium mobilization (KB = 0.93 nM) in CHO cells. It inhibits electrically induced twitches in isolated mouse and rat vas deferens, as well as isolated guinea pig ileum, when used at a concentration of 100 nM. BAN ORL 24 (10 mg/kg) reverses thermal and mechanical antinociceptive activities induced by the dual agonist of µ-opioid and NOP receptors BPR1M97 in mice.{62410}

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