Bambuterol (hydro<wbr>chloride)

Bambuterol (hydrochloride)

CAT N°: 17887
Price:

From 48.00 40.80

Bambuterol is a prodrug form of the ?-adrenergic receptor (?-AR) agonist terbutaline (Item No. 29337).{29051,25395} It is also an inhibitor of butyrylcholinesterase (BChE; IC50 = 3.9 nM for the human enzyme), the enzyme that metabolizes bambuterol into terbutaline, and this inhibition increases the duration of action of terbutaline.{29051,57423} Bambuterol (1 and 2 mg/kg) increases the latency to histamine-induced collapse in guinea pigs.{57422} It completely inhibits ovalbumin-induced decreases in dynamic compliance and increases in pulmonary resistance in ovalbumin-sensitized guinea pigs when administered at a dose of 10 mg/kg. Formulations containing bambuterol have been used in the treatment of asthma.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N,N-dimethyl-carbamic acid-3-[[(dimethylamino)carbonyl]oxy]-5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]phenyl ester, monohydrochloride
  • Correlated keywords
    • 81732-65-2 biochemical receptor agonist signal transduction allergy asthma Bambec KWD2183 prodrug pro-drug terbutaline HCl
  • Product Overview:
    Bambuterol is a prodrug form of the ?-adrenergic receptor (?-AR) agonist terbutaline (Item No. 29337).{29051,25395} It is also an inhibitor of butyrylcholinesterase (BChE; IC50 = 3.9 nM for the human enzyme), the enzyme that metabolizes bambuterol into terbutaline, and this inhibition increases the duration of action of terbutaline.{29051,57423} Bambuterol (1 and 2 mg/kg) increases the latency to histamine-induced collapse in guinea pigs.{57422} It completely inhibits ovalbumin-induced decreases in dynamic compliance and increases in pulmonary resistance in ovalbumin-sensitized guinea pigs when administered at a dose of 10 mg/kg. Formulations containing bambuterol have been used in the treatment of asthma.

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