AZD 8835

AZD 8835

CAT N°: 29166
Price:

From 55.00 46.75

AZD 8835 is an inhibitor of PI3K? and PI3K? (IC50s = 6.2 and 5.7 nM, respectively).{48678} It is selective for PI3K? and PI3K? over PI3K? and PI3K? (IC50s = 431 and 90 nM, respectively). AZD 8835 inhibits Akt phosphorylation in PIK3CA constitutively active mutant BT474 cells and Jeko-1 B cells that express endogenous PI3K? (IC50s = 57 and 49 nM, respectively). In vivo, AZD 8835 (25 mg/kg) reduces tumor growth and Akt phosphorylation in a SKOV3 mouse xenograft model. It also increases the activity of CD8+ effector T cells and reduces tumor growth in a C26 mouse syngeneic tumor model.{48679}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-[4-[5-[5-amino-6-[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]-2-pyrazinyl]-1-ethyl-1H-1,2,4-triazol-3-yl]-1-piperidinyl]-3-hydroxy-1-propanone
  • Correlated keywords
    • AZD8835 PI3K ? ? ? ? PI3 K? K? K? K? PIK 3CA BT 474 Jeko1 SKOV 3 SK OV OV3 CD 8 C 26
  • Product Overview:
    AZD 8835 is an inhibitor of PI3K? and PI3K? (IC50s = 6.2 and 5.7 nM, respectively).{48678} It is selective for PI3K? and PI3K? over PI3K? and PI3K? (IC50s = 431 and 90 nM, respectively). AZD 8835 inhibits Akt phosphorylation in PIK3CA constitutively active mutant BT474 cells and Jeko-1 B cells that express endogenous PI3K? (IC50s = 57 and 49 nM, respectively). In vivo, AZD 8835 (25 mg/kg) reduces tumor growth and Akt phosphorylation in a SKOV3 mouse xenograft model. It also increases the activity of CD8+ effector T cells and reduces tumor growth in a C26 mouse syngeneic tumor model.{48679}

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