AZD 1981

AZD 1981

CAT N°: 20763
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AZD 1981 is a DP2/CRTH2 receptor antagonist (IC50 = 3.98 nM).{32940} It is selective for DP2 over a panel of receptors, ion channels, transporters, and enzymes, including DP1, COX-1, and COX-2, at 10 µM. AZD 1981 (3-100 nM) inhibits increases in the expression of CD11b, a cell adhesion molecule, induced by 13,14-dihydro-15-keto-prostaglandin D2 (13,14-dihydro-15-keto-PGD2; Item No. 12610) in isolated human eosinophils. It also inhibits 13,14-dihydro-15-keto-PGD2-induced chemotaxis of isolated human eosinophils and T cells in a concentration-dependent manner.

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