AZD 1283

AZD 1283

CAT N°: 27649
Price:

From 48.00 40.80

AZD 1283 is an antagonist of the purinergic P2Y12 receptor (IC50 = 25 nM in a GTP?S assay in CHO cells).{52053} It selectively binds to the P2Y12 receptor (Kd = 11 nM) over more than 100 enzymes, receptors, and ion channels, including the P2Y1, platelet activating factor (PAF), and thromboxane A2 receptors, at 10 µM.{52053},{52054} AZD 1283 increases blood flow and inhibits platelet aggregation induced by ADP in a modified Folts dog model of thrombosis with ED50 values of 3 and 10 µg/kg per minute, respectively.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylic acid, ethyl ester
  • Correlated keywords
    • AZD1283 P2Y
  • Product Overview:
    AZD 1283 is an antagonist of the purinergic P2Y12 receptor (IC50 = 25 nM in a GTP?S assay in CHO cells).{52053} It selectively binds to the P2Y12 receptor (Kd = 11 nM) over more than 100 enzymes, receptors, and ion channels, including the P2Y1, platelet activating factor (PAF), and thromboxane A2 receptors, at 10 µM.{52053},{52054} AZD 1283 increases blood flow and inhibits platelet aggregation induced by ADP in a modified Folts dog model of thrombosis with ED50 values of 3 and 10 µg/kg per minute, respectively.

We also advise you