AZD 1152-<wbr/>HQPA

AZD 1152-HQPA

CAT N°: 11602
Price:

From 48.00 40.80

AZD 1152-HQPA is an inhibitor of Aurora kinase B (IC50 = 0.37 nM) that demonstrates ~3,700-fold greater selectivity for Aurora kinase B over Aurora kinase A (IC50 = 1.368 µM).{31459,31461} It does not have activity against a panel of 50 other serine-threonine or tyrosine kinases, including FLT3, JAK2, and Abl.{31459,31461} AZD 1152-HQPA has been shown to inhibit the proliferation of hematopoietic malignant cells (IC50s = 3-40 nM), disrupting spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis, and to inhibit tumor xenograft growth in vivo.{31461,31460}

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