AUY954

AUY954

CAT N°: 9000548
Price:

From 102.00 86.70

AUY954 is an orally bioavailable and selective agonist of the sphingosine-1-phosphate receptor 1 (S1P1; EC50 = 1.2 nM for stimulating GTP?S binding to S1P1 in CHO cells).{14536} It is highly selective for the S1P1 receptor with EC50 values of >10,000, 1,210, >1,000, and 340 nM for S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 reduces circulating lymphocytes and prevents rejection of rat heart allografts. In a rat model of experimental autoimmune neuritis, chronic treatment with AUY954 (10 mg/kg), starting on the day of immunization, almost completely prevents peripheral paralysis.{37100} In the same model, it also decreases T cell, B cell, and macrophage infiltration and perivascular demyelination in sciatic nerves.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[[2-[2-(trifluoromethyl)[1,1′-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-?-alanine
  • Correlated keywords
    • 820240-78-6 AUY-954 S1P-1 2 3 4 5 chinese hamster ovary GTPgs
  • Product Overview:
    AUY954 is an orally bioavailable and selective agonist of the sphingosine-1-phosphate receptor 1 (S1P1; EC50 = 1.2 nM for stimulating GTP?S binding to S1P1 in CHO cells).{14536} It is highly selective for the S1P1 receptor with EC50 values of >10,000, 1,210, >1,000, and 340 nM for S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 reduces circulating lymphocytes and prevents rejection of rat heart allografts. In a rat model of experimental autoimmune neuritis, chronic treatment with AUY954 (10 mg/kg), starting on the day of immunization, almost completely prevents peripheral paralysis.{37100} In the same model, it also decreases T cell, B cell, and macrophage infiltration and perivascular demyelination in sciatic nerves.

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