Aureusimine B

Aureusimine B

CAT N°: 18752
Price:

From 322.00 273.70

Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus.{31506,31173} Its synthesis appears to be initiated by a conserved nonribosomal peptide synthetase that creates a dipeptide (phenylalanine-valine) aldehyde, which then undergoes cyclization and oxidation.{31173} Aureusimine B inhibits calpain in a casein hydrolysis assay (IC50 = 1.3 µM), contributes to S. aureus infection in mice, and alters human keratinocyte gene expression.{31506,31507,31508}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-(1-methylethyl)-6-(phenylmethyl)-2(1H)-pyrazinone
  • Correlated keywords
    • pyrazinone phe-val F-V
  • Product Overview:
    Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus.{31506,31173} Its synthesis appears to be initiated by a conserved nonribosomal peptide synthetase that creates a dipeptide (phenylalanine-valine) aldehyde, which then undergoes cyclization and oxidation.{31173} Aureusimine B inhibits calpain in a casein hydrolysis assay (IC50 = 1.3 µM), contributes to S. aureus infection in mice, and alters human keratinocyte gene expression.{31506,31507,31508}

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