Aurantio<wbr/>obtusin

Aurantioobtusin

CAT N°: 27481
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122.00 103.70

Aurantioobtusin is an anthraquinone originally isolated from Cassia seeds with diverse biological activities.{47459,47460,47461,47462,47463} It inhibits rat lens aldose reductase (RLAR) in vitro (IC50 = 13.6 ?M).{47459} Aurantioobtusin (10 and 100 ?M) activates the aryl hydrocarbon receptor (AhR) in a concentration-dependent manner.{47460} It inhibits rat platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), ADP, and collagen.{47461} Aurantioobtusin induces vasorelaxation in isolated precontracted rat mesenteric artery rings, an effect that is inhibited by the PI3K inhibitor LY290042 or inhibition of endothelial nitric oxide synthase (eNOS).{47462} It is larvicidal against A. gambiae mosquitoes (LD50 = 10 ppm).{47463}

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