α-Asarone

α-Asarone

CAT N°: 11681
Price:

From 39.00 33.15

α-Asarone is a component of certain essential oils used in traditional Chinese herbal medicine. Although carcinogenic, α-asarone has been shown to be neuroprotective and radioprotective in mice when given at 50 mg/kg.{21103,21108,21096} It also lowers serum cholesterol in rats, specifically reducing LDL-cholesterol levels and cholesterol saturation index, by directly inhibiting HMG-CoA reductase (IC50 = 3 mM).{21107,21098} α-Asarone also directly interacts with and inhibits certain isoforms of cytochrome P450 (IC50 = 55.2 and 65.2 μg/ml for CYP2D6 and CYP3A4, respectively).{21106}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1,2,4-trimethoxy-5-(1E)-1-propen-1-yl-benzene
  • Correlated keywords
    • 1,2,4-trimethoxy-5-(1-propenyl)-benzene 1,2,4-trimethoxy-5-(1E)-1-propenyl-benzene Isoasaron (E)-Asarone Asarum camphor trans-Asaron trans-Isoasarone essential oils inhibitors carcinogenic cancers neuroprotection radioprotection DNA deoxyribonucleic acids neuronal damages cholesterols LDL-cholesterols HMG-CoA reductases cytochromes P450 CYP450 CYPs CYP-450 HMGCoA HMG coenzymes A CoA isoforms inhibits inhibition chinese medicines mice mouse murine serums rats low density lipoproteins levels saturation index CYP2D6 2D6 CYP3A4 3A4
  • Product Overview:
    α-Asarone is a component of certain essential oils used in traditional Chinese herbal medicine. Although carcinogenic, α-asarone has been shown to be neuroprotective and radioprotective in mice when given at 50 mg/kg.{21103,21108,21096} It also lowers serum cholesterol in rats, specifically reducing LDL-cholesterol levels and cholesterol saturation index, by directly inhibiting HMG-CoA reductase (IC50 = 3 mM).{21107,21098} α-Asarone also directly interacts with and inhibits certain isoforms of cytochrome P450 (IC50 = 55.2 and 65.2 μg/ml for CYP2D6 and CYP3A4, respectively).{21106}

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