AS-<wbr/>041164

AS-041164

CAT N°: 13622
Price:

From 108.00 91.80

The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism.{17822} AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3K? (IC50 = 70 nM), compared to PI3K? (IC50 = 240 nM), PI3K? (IC50 = 1.45 ?M), and PI3K? (IC50 =1.70 ?M).{17823} When tested at 1.0 ?M, it shows little or no activity against 38 other common kinases.{17823} When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.{17823}

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