Araguspongin B

Araguspongin B

CAT N°: 10006797
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From 601.00 510.85

Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.{9844} Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.{8344} Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC50 of 0.6 µM.{9845} It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.

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