Arachidonoyl Glycine

Arachidonoyl Glycine

CAT N°: 90051
Price:

From 62.00 52.70

Arachidonoyl glycine (N-arachidonyl glycine; NAGly) has been isolated from cell cultures treated with arachidonoyl ethanolamide (AEA; anandamide),{9578} from extracts of mammalian brain,{9579,9589} and has also been synthesized as an analog of AEA for structure/activity testing.{9580} NAGly may be produced endogenously via oxidation of AEA, or by transacylation of arachidonoyl CoA. NAGly is reported to have analgesic activities in whole animal experiments.{9578,9579,9589} Since it seems to be a very poor ligand for the CB1 receptor,{9580} these effects are probably mediated via other signaling pathways.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl]-glycine
  • Correlated keywords
    • cannabinoids ligands lipids CB1 receptors AEA anandamides ethanolamides fatty acids neurochemistry neuroscience N-arachidonoylglycine
  • Product Overview:
    Arachidonoyl glycine (N-arachidonyl glycine; NAGly) has been isolated from cell cultures treated with arachidonoyl ethanolamide (AEA; anandamide),{9578} from extracts of mammalian brain,{9579,9589} and has also been synthesized as an analog of AEA for structure/activity testing.{9580} NAGly may be produced endogenously via oxidation of AEA, or by transacylation of arachidonoyl CoA. NAGly is reported to have analgesic activities in whole animal experiments.{9578,9579,9589} Since it seems to be a very poor ligand for the CB1 receptor,{9580} these effects are probably mediated via other signaling pathways.

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