Arachidonoyl-<wbr/>1-<wbr/>thio-<wbr/>Glycerol

Arachidonoyl-1-thio-Glycerol

CAT N°: 10007904
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From 43.00 36.55

2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the central cannabinoid (CB1) receptor.{7182,7183} It is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol found in rat brain.{7183,6819} Monoacylglycerol lipase (MAGL) hydrolyzes 2-AG to arachidonic acid and glycerol, thereby terminating its biological actions.{11364} Arachidonoyl-1-thio-glycerol is a thioester substrate analog of 2-arachidonoyl glycerol that can be utilized for the measurement of MAGL activity.{13593} Hydrolysis of the thioester bond by MAGL generates a free thiol that reacts rapidly with the chromogenic reagent DTNB (Ellman’s reagent) resulting a yellow product with an absorbance maximum at 412 nm.

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