Apocynin

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 1-(4-hydroxy-3-methoxyphenyl)-ethanone
• Correlated keywords
  • antioxidants NADPH oxidase superoxide O2- immunology inflammations arthritis atherosclerosis anti-inflammatory antiinflammatory inflammatory plants picrorhiza kurroa p. vanillin inhibitors inhibits inhibitions nicotinamide adenine dinucleotides phosphates reactive oxygen species ROS immune systems treatments arthritis bowl movements diseases asthma atherosclerosis familial amyotropic lateral sclerosis ALS oxidative injury natural immunology NSC2146 NSC-2146 NSC209524 NSC-209524 acetoguaiacon apocynine acetoguaicone Picrorhiza anti-oxidant antiinflammatory TNF? i-NOS IL1?
• Product Overview:
  Apocynin is an acetophenone originally isolated from P. kurroa that has antioxidant and anti-inflammatory activities.{22115,69163} It inhibits glucose production in H-4-II-E-C3 cells (IC50 = 25 µM).{69164} Apocynin inhibits the production of superoxide anions induced by PMA (Item No. 10008014) in isolated human leukocytes in a concentration-dependent manner.{22115} It increases nitric oxide (NO) bioavailability in rat carotid arterial rings isolated from spontaneously hypertensive stroke-prone (SHRSP) rats when used at concentrations of 0.3 or 3 mM.{69165} Apocynin (5 mg/kg) reduces lung injury and pulmonary TNF-? and IL-1? levels in a mouse model of pleurisy induced by carrageenan.{69163} It inhibits I?B? degradation and reduces NF-?B p65 and inducible nitric oxide synthase (iNOS) protein levels in the same model. Formulations containing apocynin have been used in the treatment of rheumatoid arthritis, osteoarthritis, bronchial asthma, and chronic obstructive pulmonary disease (COPD).