Anthrax Lethal Factor (recombinant from Bacillus anthracis), Native Sequence (LF-A)

CAT N°: 28874
Price:

732.00 622.20

Anthrax lethal factor is one component of a tripartite protein toxin secreted into host systems during anthrax infection by B. anthracis.{36341} The toxin is a mixture of three protein components: Lethal factor, edema factor, and protective antigen. Lethal factor is a zinc-dependent metalloprotease that disrupts MAPK signaling by cleaving MAPK kinases near the N-terminal end. It requires protective antigen (PA), but not edema factor (EF), for its lethality. LF-A, in combination with PA, is lethal to RAW 264.7 cells (EC50 = 1.2 ng/ml) and rats when administered at doses of 10 and 100 µg/animal, respectively.{46465}

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