Anthralin

Anthralin

CAT N°: 28371
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From 48.00 40.80

Anthralin is an anthrone inhibitor of keratinocyte proliferation and a modulator of differentiation.{45558} It increases apoptosis and inhibits proliferation of normal human keratinocytes (NHKs) when used at a concentration of 2.5 ?M. It also decreases the mitochondrial membrane potential, increases cytochrome c release, and induces perinuclear mitochondrial clustering in NHKs when used at a concentration of 5 ?M.{45559} Anthralin (0.25 ?M) decreases the expression of ?-defensin-2 (Item No. 24577) and S100 calcium-binding protein A9 (S100A9) and increases the expression of IL-6 and IL-8 in IL-17A- and IL-22-stimulated NHKs.{45558} It also inhibits leukotriene B4 (LTB4; Item No. 20110) production, stimulated by the calcium ionophore A23187 (Item No. 11016), from human neutrophils (IC50 = 7 ?M).{342} Topical anthralin (0.1%) induces hair regrowth in a Dundee experimental bald rat (DEBR) model of alopecia areata.{45560}

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