€724.00 €615.40
Annexin V is a soluble membrane-binding protein encoded by the ANXA5 gene in humans that binds to negatively charged phospholipids, such as phosphatidylserine (PS), in a calcium-dependent manner.{53209,53210,53211} It is expressed in a wide variety of tissues but is detected primarily in placenta and vascular endothelium.{53212} Annexin V is comprised of a variable N-terminal domain and four highly conserved annexin repeats that form the membrane-binding core.{53209,53213} Upon membrane binding, annexin V forms a two-dimensional lattice that is stabilized by protein-protein interactions.{53210,53213} In activated platelets and apoptotic cells, plasma membrane asymmetry, but not integrity, is disrupted and PS becomes exposed at the cell surface, following which annexin V binds to the surface-exposed PS and inhibits its procoagulant and pro-inflammatory activities.{53210,53212,53214,18062} Because of its affinity for PS in apoptotic cell membranes, fluorescent and affinity-labeled versions of annexin V have been used in affinity assays for the detection and quantification of apoptotic cells.{18062} Annexin V levels are elevated in tumor tissue from patients with a variety of cancers, including follicular thyroid adenoma, papillary thyroid carcinoma, cervical squamous cell carcinoma, and colorectal cancer.{53213} Cayman’s Annexin V (human, recombinant) protein can be used for Western blot, ELISA, and cell-based assays.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | PBS, pH 7.4, with 10% glycerol |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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