Andrographolide

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 3E-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4S-hydroxy-2(3H)-furanone
• Correlated keywords
  • andrographis andrographolid 5953-53-7 101060-34-8 diterpenoids medicinal plants immunosuppression antithrombosis anti-inflammatory anti-inflammatory anti inflammatory antineoplastic anti-neoplastic neoplastic anti-viral antiviral viral anti-bacterial antibacterial bacterial anti-diabetic antidiabetic diabetics anti-oxidative stress antioxidative oxiddative antipyretic anti-pyretic pyretic anti-oedematogenic antioedematogenic anti-nociceptive antinociceptive nociceptive nuclear factor kappa B NF-?B p50 CYP1A endothelial cells E-selectin neutrophils allergic inflammations asthma CYP450 eselectin E selectin signaling signalling Andrographis paniculata inhibits inhibition inhibitors NF?B NF ?B DNA anti-edematogenic antiedematogenic
• Product Overview:
  Andrographolide is a labdane diterpenoid that is the main bioactive component of A. paniculata, a well-recognized medicinal plant in Asia. It exerts a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, antiviral, antibacterial, antidiabetic, antioxidative stress, antipyretic, antioedematogenic, and antinociceptive activities.{21112} Andrographolide treatment inhibits nuclear factor kappa B (NF-?B) binding to DNA promoters of target genes (IC50 = ~15 ?M), by forming a covalent adduct with reduced cysteine (62) of the NF-?B p50 subunit, and can also induce expression of the CYP1A subfamily of the cytochrome P450 family of enzymes.{21113,21111} At 5 ?g/g body weight it can suppress the activation of NF-?B in stimulated endothelial cells, reducing the expression of the cell adhesion molecule E-selectin, abrogating the cytokine- and endotoxin-induced peritoneal infiltration of neutrophils, attenuating septic shock, and preventing allergic lung inflammation in a mouse model of asthma.{21111}