€672.00 €571.20
Androgen receptor is a ligand-activated transcription factor and member of the steroid hormone receptor family.{59547,59546} It is composed of an N-terminal regulatory domain (AF-1 site), a DNA-binding domain that contains two zinc fingers, a hinge region containing a nuclear localization signal, and a C-terminal ligand-binding domain (AF-2 site). Unligated androgen receptors are localized to the cytoplasm and bound to heat shock protein 23 (Hsp23), -56, -70, and -90 in a stable conformation that facilitates androgen binding. Androgen binding induces dissociation of the Hsps and nuclear translocation of the androgen receptor where it binds to androgen response elements (AREs) and induces gene transcription. Mutations in AR, the gene encoding the androgen receptor, induce abnormalities in male development ranging from partial androgen insensitivity to complete male-to-female phenotypic sex reversal.{59546} Androgen receptor knockdown induces bone loss, complete loss of sexual behaviors, and reduced aggressive behaviors in male mice, as well as defective folliculogenesis and reduced fertility in female mice. Expression of C-terminally truncated and constitutively active androgen receptor mutants are associated with reduced progression-free survival, lower prostate-specific androgen (PSA) response rates, and shorter median overall survival in patients with castration-resistant prostate cancer.{59548} Cayman’s Androgen Receptor (N-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes the N-terminus to detect the full-length androgen receptor and its splice variants from human samples.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide from the N-terminal region of the human androgen receptor |
| Clone | RM254 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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